3005859
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Sertraline, Serum or Plasma

SERTRAL SP
Example Reports
High
Therapeutic

Ordering Recommendation

Use to optimize drug therapy and monitor patient adherence.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.

Collect

Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2EDTA).

Specimen Preparation

Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).

Remarks
Stability

After separation from cells: Ambient: 24 hours; Refrigerated: 2 weeks; Frozen: 4 months

Methodology

Liquid Chromatography-Tandem Mass Spectrometry

Performed

Wed

Reported

1-8 days

Reference Interval

Test Number
 Components
 Reference Interval
  Sertraline_Serum or Plasma
Therapeutic Range: 30-200 ng/mL
Toxic: Greater than 300 ng/mL

Interpretive Data

Sertraline is a selective serotonin reuptake inhibitor antidepressant drug indicated for the treatment of major depressive disorder, obsessive-compulsive disorder, posttraumatic stress disorder, social anxiety disorder, and premenstrual dysphoric disorder. Sertraline doses range from 50-200 mg/day to produce serum concentration that range from 30-200 ng/mL. Dosing above 200 mg/day may increase the risk of adverse effects. Adverse effects may include dry mouth, headache, dizziness, fatigue, somnolence, tremor, nausea, and diarrhea. The risk of serotonin syndrome is increased with concomitant use of other serotonergic drugs. Concomitant use of sertraline with anticoagulants and nonsteroidal anti-inflammatory drugs may increase the risk of bleeding.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the U.S. Food and Drug Administration. This test was performed in a CLIA-certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)

Note

Hotline History

N/A

CPT Codes

80332 (Alt code: G0480)

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Components

Component Test Code* Component Chart Name LOINC
3005861 Sertraline_Serum or Plasma
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

Sertraline, Serum or Plasma